Daniel LaBarbera

About

Work

University of Colorado Anschutz Medical Campus
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Professor and Director, The CU Anschutz Center for Drug Discovery

US

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Education

University of Utah
United States of America

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NIH NRSA Postdoctoral Fellowship

Arizona State University
United States of America

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PhD

Publications

Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects in Breast and Colorectal Cancer

Published by

Cells

Summary

journal-article

Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects in Breast and Colorectal Cancer

Published by

Cells

Summary

journal-article

CHD1L Inhibitor OTI-611 Synergizes with Chemotherapy to Enhance Antitumor Efficacy and Prolong Survival in Colorectal Cancer Mouse Models

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International Journal of Molecular Sciences

Summary

journal-article

CHD1L Inhibitor OTI-611 Synergizes with Chemotherapy to Enhance Antitumor Efficacy and Prolong Survival in Colorectal Cancer Mouse Models

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International Journal of Molecular Sciences

Summary

journal-article

Validation of ferroptosis in canine cancer cells to enable comparative oncology and translational medicine

Summary

preprint

HTS discovery of PARP1-HPF1 complex inhibitors in cancer

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SLAS Discovery

Summary

journal-article

The validation of new CHD1L inhibitors as a therapeutic strategy for cancer.

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Summary

journal-article

Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L.

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Journal of medicinal chemistry

Summary

journal-article

AST-487 Inhibits RET Kinase Driven TERT Expression in Bladder Cancer.

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International journal of molecular sciences

Summary

journal-article

High-Content Drug Discovery Targeting Molecular Bladder Cancer Subtypes.

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International journal of molecular sciences

Summary

journal-article

Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21.

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Free radical biology & medicine

Summary

journal-article

TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer

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Proceedings of the National Academy of Sciences

Summary

journal-article

Isolating and targeting the real-time plasticity and malignant properties of epithelial-mesenchymal transition in cancer.

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Oncogene

Summary

journal-article

Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo.

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Molecular carcinogenesis

Summary

journal-article

High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling.

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Arteriosclerosis, thrombosis, and vascular biology

Summary

journal-article

First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer.

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Molecular cancer therapeutics

Summary

journal-article

Advanced High-Content-Screening Applications of Clonogenicity in Cancer.

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SLAS discovery : advancing life sciences R & D

Summary

journal-article

Advanced High-Content-Screening Applications of Clonogenicity in Cancer

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SLAS Discovery

Summary

journal-article

Establishment and Characterization of Four Novel Thyroid Cancer Cell Lines and PDX Models Expressing the RET/PTC1 Rearrangement, BRAFV600E, or RASQ61R as Drivers.

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Molecular cancer research : MCR

Summary

journal-article

Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer.

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Journal of medicinal chemistry

Summary

journal-article

Targeting HIV-1 Protease Autoprocessing for High-throughput Drug Discovery and Drug Resistance Assessment

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Scientific Reports

Summary

journal-article

Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers.

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Clinical cancer research : an official journal of the American Association for Cancer Research

Summary

journal-article

Identification of small molecule inhibitors of the Chikungunya virus nsP1 RNA capping enzyme.

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Antiviral research

Summary

journal-article

Identification of small molecule inhibitors of the Chikungunya virus nsP1 RNA capping enzyme

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Antiviral Research

Summary

journal-article

Inhibition of α-glucosidase, α-amylase, and aldose reductase by potato polyphenolic compounds.

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PloS one

Summary

journal-article

SBI<sup>2</sup> HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium.

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Assay and drug development technologies

Summary

journal-article

Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri.

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PLoS neglected tropical diseases

Summary

journal-article

Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri

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PLOS Neglected Tropical Diseases

Summary

journal-article

Cross talk between progesterone receptors and retinoic acid receptors in regulation of cytokeratin 5-positive breast cancer cells.

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Oncogene

Summary

journal-article

3D High-Content Screening of Organoids for Drug Discovery

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Comprehensive Medicinal Chemistry III

Summary

book-chapter

High-throughput imaging: Focusing in on drug discovery in 3D

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Methods

Summary

journal-article

3D Cellular Imaging – Advances and Considerations for High-Content Screening

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Drug Discovery World

Summary

magazine-article

Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract.

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Journal of natural products

Summary

journal-article

Topoisomerase IIα mediates TCF-dependent epithelial-mesenchymal transition in colon cancer.

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Oncogene

Summary

journal-article

High-throughput imaging: Focusing in on drug discovery in 3D.

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Methods (San Diego, Calif.)

Summary

journal-article

Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities.

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Journal of medicinal chemistry

Summary

journal-article

ChemInform Abstract: The Synthesis of Vinylogous Amidine Heterocycles.

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ChemInform

Summary

journal-article

Live multicellular tumor spheroid models for high-content imaging and screening in cancer drug discovery.

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Current chemical genomics and translational medicine

Summary

journal-article

Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells.

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Chemico-biological interactions

Summary

journal-article

An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: an ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent.

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Marine drugs

Summary

journal-article

Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia.

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Investigative ophthalmology & visual science

Summary

journal-article

The synthesis of vinylogous amidine heterocycles.

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The Journal of organic chemistry

Summary

journal-article

Neoamphimedine, a Lead Anti-Metastatic Agent for the Treatment of Drug Resistant and Metastatic Colorectal Cancer

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Planta Medica

Summary

journal-article

Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase.

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Journal of medicinal chemistry

Summary

journal-article

The Synthesis of Vinylogous Amidine Heterocycles

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The Journal of Organic Chemistry

Summary

journal-article

The multicellular tumor spheroid model for high-throughput cancer drug discovery.

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Expert opinion on drug discovery

Summary

journal-article

The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis.

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PloS one

Summary

journal-article

Beta-glucogallin reduces the expression of lipopolysaccharide-induced inflammatory markers by inhibition of aldose reductase in murine macrophages and ocular tissues.

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Chemico-biological interactions

Summary

journal-article

Progesterone-inducible cytokeratin 5-positive cells in luminal breast cancer exhibit progenitor properties.

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Hormones & cancer

Summary

journal-article

A high-content assay to identify small-molecule modulators of a cancer stem cell population in luminal breast cancer.

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Journal of biomolecular screening

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journal-article

Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIα activity through ATP-competitive inhibition.

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Marine drugs

Summary

journal-article

3D models of epithelial-mesenchymal transition in breast cancer metastasis: high-throughput screening assay development, validation, and pilot screen.

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Journal of biomolecular screening

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journal-article

The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells.

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Anti-cancer drugs

Summary

journal-article

ChemInform Abstract: The Total Synthesis of Neoamphimedine.

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ChemInform

Summary

journal-article

Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition.

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Journal of medicinal chemistry

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journal-article

Synthesis and biological evaluation of imidazoquinoxalinones, imidazole analogues of pyrroloiminoquinone marine natural products.

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Journal of medicinal chemistry

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journal-article

Halogenated cyclic peptides isolated from the sponge Corticium sp.

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Journal of natural products

Summary

journal-article

The total synthesis of neoamphimedine.

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The Journal of organic chemistry

Summary

journal-article

Solution kinetics of CC-1065 A-ring opening: substituent effects and general acid/base catalysis.

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Journal of the American Chemical Society

Summary

journal-article

Synthesis of imidazo[1,5,4-de]quinoxalin-9-ones, benzimidazole analogues of pyrroloiminoquinone marine natural products.

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Bioorganic & medicinal chemistry

Summary

journal-article